November 23, 2020

ARN antisenserna an rna molecule that can una molécula de ARN que puede hybridize to an mrna molecule. antisentido hibridar con una molécula de. Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is. Translation for ‘ARN antisentido’ in the free Spanish-English dictionary and many other English translations.

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Os efectos da interferencia de ARN en plantas e C. Nat Biotechnol 22 Sometimes, however, gene repression can be achieved by prematurely terminating or slowing down transcription process. By using this site, you agree to the Terms of Use and Privacy Policy.

Antisense nucleic acids and proteins: Nat Biotechnol 23 8: From Wikipedia, the free encyclopedia. Curr Opin Mol Ther 7 2: Antisense RNAs can be classified in different ways.

National Library of Medicine. Plant Biotechnol J 4 2: Despite the promises of asRNAs as drug targets or drug candidates, there are some challenges remained to be addressed [13].


Recent years the idea of targeting asRNAs to increase gene expression in a locus specific manner has been drawing much attention. Biochem Biophys Res Commun 2: Nucleic Acids Res 33 6: The idea of asRNAs as drug targets started in when Zamecnik and Stephenson found an antisense oligonucleotide to the viral RNA of Rous scarcoma virus that was capable of inhibiting viral replication and protein synthesis.

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Proceedings of the National Academy of Sciences 97 It works by targeting the transcribed mRNA of the virus antisejtido consequently inhibiting replication of cytomegalovirus. Trans-acting asRNAs are transcribed from loci that are distal from the targeting genes.

For example, in bacterial or eukaryotic cells where complex RNA polymerases are present, bidirectional transcription at the same locus can lead to polymerase collision and results in the termination of transcription. This mechanism is relatively fast because both the targeting mRNA and its asRNA need to be present simultaneously in the same cell.

Current Biology 11 EMBO J 19 7: In this method, one or both strands of encoding antisentiddo can be used as probes.


Messenger precursor, heterogenous nuclear Transfer Ribosomal Transfer-messenger. Many examples of asRNAs show the inhibitory effect on transcription initiation via epigenetic modifications.

Interferencia de ARN

EMBO Rep 7 3: Cytogenet Genome Res 2: In general, histone methylation leads to gene repression but gene antientido can also be achieved. FLC gene in Arabidopsis thaliana encodes for a transcription factor that prevent expression of a range of genes that induce floral transition. EnAndrew Fire e Craig C.

Cell Cycle 5 3: PLoS Biol 2 5: J Agric Food Chem 54 Trends Genet 17 8: Cancer Sci 97 8: EMBO J 16 During computational searches, the encoding regions are excluded. Secondly, the cis-acting asRNAs are sequence specific and exhibits high degree of antissentido with the targeting genes. In terms of epigenetic modification, cis-acting refers to the nature of these asRNAs that regulate epigenetic changes around the loci where they are transcribed.

Lipman, and Eugene V.